abstract：:Avian infectious bronchitis virus (IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopatho...

journal_title：Virologica Sinica

authors： He Y,Xie Z,Dai J,Cao Y,Hou J,Zheng Y,Wei T,Mo M,Wei P

更新日期：2016-02-01 00:00:00

abstract：:Recreational waters contaminated with human fecal pollution are a public health concern, and ensuring the safety of recreational waters for public use is a priority of both the Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention (CDC). Current recreational water standards rely on f...

journal_title：Virologica Sinica

authors： Updyke EA,Wang Z,Sun S,Connell C,Kirs M,Wong M,Lu Y

更新日期：2015-10-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the key underlying cause of acute lower respiratory tract infection in infants; however, no licensed vaccine against RSV infection is currently available. This study was undertaken to assess the preventive effect of vaccine on RSV infection. In this metaanalysis, 1,792 published ra...

journal_title：Virologica Sinica

authors： Zhu T,Zhang C,Yu L,Chen J,Qiu H,Lyu W,Huang S

更新日期：2015-10-01 00:00:00

abstract：:Herpesviruses are a prominent cause of human viral disease, second only to the cold and influenza viruses. Most herpesvirus infections are mild or asymptomatic. However, when the virus invades the eye, a number of pathologies can develop and its associated sequelae have become a considerable source of ocular morbidity...

journal_title：Virologica Sinica

authors： Zhu L,Zhu H

更新日期：2014-12-01 00:00:00

abstract：:Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinob...

journal_title：Virologica Sinica

authors： Jiménez LF,Ramírez Nieto G,Alfonso VV,Correa JJ

更新日期：2014-08-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is still a worldwide health problem; however, the current antiviral therapies for chronic hepatitis B are limited in efficacy. The outcome of HBV infection is thought to be the result of complex interactions between the HBV and the host immune system. While the role of the adaptive im...

journal_title：Virologica Sinica

authors： Chen J,Yuan Z

更新日期：2014-02-01 00:00:00

abstract：:During transcription initiation, RNA polymerase binds tightly to the promoter DNA defining the start of transcription, transcribes comparatively slowly, and frequently releases short transcripts (3-8 nucleotides) in a process called abortive cycling. Transitioning to elongation, the second phase of transcription, the ...

journal_title：Virologica Sinica

authors： Theis K

更新日期：2013-12-01 00:00:00

abstract：:The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated Incremental Pruning to P...

journal_title：Virologica Sinica

authors： Wang Y,Rawi R,Hoffmann D,Sun B,Yang R

更新日期：2013-08-01 00:00:00

abstract：:The construction of the first infectious clone JFH-1 speeds up the research on hepatitis C virus (HCV). However, Huh7 cell line was the only highly permissive cell line for HCV infection and only a few clones were fully permissive. In this study, two different fully permissive clones of Huh7 cells, Huh7.5.1 and Huh7-L...

journal_title：Virologica Sinica

authors： Chen H,Pei R,Chen X

更新日期：2013-08-01 00:00:00

abstract：:Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core ...

journal_title：Virologica Sinica

authors： Liao Q,Tian J,Wu Y,Chen X

更新日期：2013-06-01 00:00:00

abstract：:Bat SARS-like coronavirus (SL-CoV) has a genome organization almost identical to that of SARS-CoV, but the N-terminus of the Spike (S) proteins, which interacts with host receptor and is a major target of neutralizing antibodies against CoVs, of the two viruses has only 63-64% sequence identity. Although there have be...

journal_title：Virologica Sinica

authors： Zhou P,Han Z,Wang LF,Shi Z

更新日期：2013-04-01 00:00:00

abstract：:Shiga toxin B-subunit (STxB) from Shigella dysenteriae targets in vivo antigen to cancer cells, dendritic cells (DC) and B cells, which preferentially express the globotriaosylceramide (Gb3) receptor. This pivotal role has encouraged scientists to investigate fusing STxB with other clinical antigens. Due to the challe...

journal_title：Virologica Sinica

authors： Sadraeian M,Ghoshoon MB,Mohkam M,Karimi Z,Rasoul-Amini S,Ghasemi Y

更新日期：2013-02-01 00:00:00

abstract：:A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while...

journal_title：Virologica Sinica

authors： Wu C,Shi H,Wang Y,Lu M,Xu Y,Chen X

更新日期：2012-12-01 00:00:00

abstract：:Ebola virus (EBOV) and Marburg virus (MARV) are causative agents of severe hemorrhagic fever with high mortality rates in humans and non-human primates and there is currently no licensed vaccine or therapeutics. To date, there is no specific laboratory diagnostic test in China, while there is a national need to provid...

journal_title：Virologica Sinica

authors： Huang Y,Wei H,Wang Y,Shi Z,Raoul H,Yuan Z

更新日期：2012-10-01 00:00:00

abstract：:In this study, the decay of maternal peste des petits ruminants virus (PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids. Serum samples collected from kids born t...

journal_title：Virologica Sinica

authors： Balamurugan V,Sen A,Venkatesan G,Rajak KK,Bhanuprakash V,Singh RK

更新日期：2012-08-01 00:00:00

abstract：:Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the n...

journal_title：Virologica Sinica

authors： Wang Z,Li TY,Li JY,Chen LL,Liu YJ,Li HP,Bao ZY,Wang XL,Zhuang DM,Liu SY,Li L

更新日期：2012-06-01 00:00:00

abstract：:Isolates of Newcastle disease virus (NDV) from deceased wild and domestic pigeons in Kazakhstan were obtained from the Almaty region during 2005 and were genotypically analyzed by using reverse transcription polymerase chain reaction (RT-PCR) with primers specific to the viral fusion (F) protein gene. Part of the ampl...

journal_title：Virologica Sinica

authors： Bogoyavlenskiy A,Berezin V,Prilipov A,Usachev E,Korotetskiy I,Zaitceva I,Kydyrmanov A,Sayatov M

更新日期：2012-04-01 00:00:00

abstract：:The ubiquitin-like modifier bISG15 is an antiviral protein found in fetal bovine lung (FBL) cells. Bovine Herpesvirus 1(BHV-1), which is a viral pathogen of cattle, can infect FBL cells and induce cytopathic effects. Real-time PCR assays showed that BHV-1's infection could repress the basal or inducible transcription ...

journal_title：Virologica Sinica

authors： Liu C,Kong XH,Qiao WT,Geng YQ

更新日期：2011-12-01 00:00:00

abstract：:The aim of the work is the comparison of the epidemiology of influenza and acute respiratory virus infections (ARVI) in the Republic of Kazakhstan with the corresponding influenza epidemic in Russia induced by influenza pandemic virus A/California/07/2009 in 2009. Data on influenza and ARVI from the Republic of Kazakh...

journal_title：Virologica Sinica

authors： Karpova LS,Popovtseva NM,Stolyarova TP,Stolyarov KA,Mamadaliyev SM,Khairullin BM,Sandybayev NT,Kydyrbayev ZhK,Orynbayev MB,Ospanov KS,Baiserkin BS,Boibosinov EU

更新日期：2011-10-01 00:00:00

abstract：:Banana bunchy top virus (BBTV), family Nanaviridae, genus Babuvirus, is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana plants. It is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific region. In this study we iso...

journal_title：Virologica Sinica

authors： Yu NT,Feng TC,Zhang YL,Wang JH,Liu ZX

更新日期：2011-08-01 00:00:00

abstract：:Lepidopteran heat-tolerant (ht) cell lines have been obtained with sf-9, sf-21 and several Bombyx cells. They have a distinct karyotype, membrane lipid composition, morphology and growth kinetics from the parental cell lines. In this paper, we report the development of ht cell lines from other insect species and exami...

journal_title：Virologica Sinica

authors： Wu YL,Jiang L,Hashimoto Y,Granados RR,Li GX

更新日期：2011-06-01 00:00:00

abstract：:Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health. However, so far no specific and efficient vaccine ha...

journal_title：Virologica Sinica

authors： Wang YP,Zhang XE,Wei HP

更新日期：2011-04-01 00:00:00

abstract：:Southern rice black-streaked dwarf virus (SRBSDV) is a novel Fijivirus prevalent in rice in southern and central China, and northern Vietnam. Its genome has 10 segments of double-stranded RNA named S1 to S10 according to their size. An isolate of SRBSDV, JNi4, was obtained from naturally infected maize plants from Ji'...

journal_title：Virologica Sinica

authors： Yin X,Xu FF,Zheng FQ,Li XD,Liu BS,Zhang CQ

更新日期：2011-02-01 00:00:00

abstract：:The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 cells. HTRP was found to interact with SAP30 (mSin3A Association Protein), one of the components of co-repressor complex mSin3A, which is part of the ...

journal_title：Virologica Sinica

authors： Chen J,Li YM,Li JF,Liu LD,Liao Y,Na RX,Wang JJ,Wang LC,Li QH

更新日期：2010-12-01 00:00:00

abstract：:In this paper, in vitro anti-influenza virus activities of sulfated polysaccharide fractions from Gracilaria lemaneiformis were investigated. Cytotoxicities and antiviral activities of Gracilaria lemaneiformis polysaccharides (PGL), Gracilaria lemaneiformis polysaccharide fraction-1 (GL-1), Gracilaria lemaneiformis po...

journal_title：Virologica Sinica

authors： Chen MZ,Xie HG,Yang LW,Liao ZH,Yu J

更新日期：2010-10-01 00:00:00

abstract：:Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or c...

journal_title：Virologica Sinica

authors： Liang X,Li ZY

更新日期：2010-08-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and a proportion of cases of multicentric Castleman's disease (MCD). The ORF73 protein was cloned into pQE80L-orf73 and expressed in E.coli and purified. The expressed recombinant ORF73 was iden...

journal_title：Virologica Sinica

authors： Ouyang XX,Fu BS,Li BL,Zeng Y,Xu FH,Wang LD

更新日期：2010-06-01 00:00:00

abstract：:An exogenous avian leukosis virus (ALV) strain SDAU09C1 was isolated in DF-1 cells from one of 240 imported 1-day-old white meat-type grand parent breeder chicks. Inoculation of SDAU09C1 in ALV-free chickens induced antibody reactions specific to subgroup A or B. But gp85 amino acid sequence comparisons indicated that...

journal_title：Virologica Sinica

authors： Zhang QC,Zhao DM,Guo HJ,Cui ZZ

更新日期：2010-04-01 00:00:00

abstract：:In this study, the coding region of type O FMDV capsid protein VP1 and a series of codon optimized DNA sequences coding for VP1 amino acid residues 141-160 (epitope1), tandem repeat 200-213 (epitope2 (+2)) and the combination of two epitopes (epitope1-2) was genetically cloned into the prokaryotic expression vector pP...

journal_title：Virologica Sinica

authors： Gao SD,Du JZ,Chang HY,Cong GZ,Shao JJ,Lin T,Song S,Xie QG

更新日期：2010-02-01 00:00:00